Motif ID: SOX{8,9,10}.p2

Z-value: 2.260


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9



Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_20005704 2.903 NAV2
neuron navigator 2
chr6_-_128883125 2.753 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr7_-_27171600 2.632 HOXA9
homeobox A9
chr7_-_27171673 2.631 NM_152739
HOXA9
homeobox A9
chr10_-_123346148 2.428 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr10_+_71482362 2.415 NM_018649
H2AFY2
H2A histone family, member Y2
chr7_-_27171648 2.382 HOXA9
homeobox A9
chr10_+_71482542 2.247 H2AFY2
H2A histone family, member Y2
chr5_-_50714836 2.225 LOC642366
hypothetical LOC642366
chr5_+_50714996 2.205 ISL1
ISL LIM homeobox 1
chr11_+_101488380 1.946 NM_001195045
YAP1
Yes-associated protein 1
chr12_-_6103945 1.944 NM_000552
VWF
von Willebrand factor
chr6_+_148705421 1.853 NM_015278
SASH1
SAM and SH3 domain containing 1
chr1_+_15957832 1.843 NM_017556
FBLIM1
filamin binding LIM protein 1
chr1_-_95165037 1.810 CNN3
calponin 3, acidic
chr7_+_121300394 1.774 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr16_-_52877829 1.714 IRX3
iroquois homeobox 3
chr1_+_207668787 1.690 NM_001104548
LOC642587
NPC-A-5
chr3_-_189354510 1.628 LOC339929
hypothetical LOC339929
chr17_-_76985538 1.602


chr7_-_11838260 1.585 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr10_-_105835525 1.555 COL17A1
collagen, type XVII, alpha 1
chr10_-_105835609 1.530 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr6_-_42218692 1.517 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr2_-_164300758 1.514 NM_018086
FIGN
fidgetin
chr3_+_190990142 1.508 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr4_-_7991992 1.501 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr1_-_94475504 1.496 ARHGAP29
Rho GTPase activating protein 29
chr8_-_29262240 1.493 NM_057158
DUSP4
dual specificity phosphatase 4
chr3_-_150993299 1.449 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr14_+_85066265 1.436 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_197173159 1.418 LOC100131234
familial acute myelogenous leukemia related factor
chr5_+_50714714 1.401 NM_002202
ISL1
ISL LIM homeobox 1
chr17_-_36996611 1.385 NM_000526
KRT14
keratin 14
chr3_+_189354167 1.384 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr16_-_52877868 1.380 NM_024336
IRX3
iroquois homeobox 3
chr1_+_64012154 1.369 NM_001083592
NM_005012
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr10_+_24795446 1.361 KIAA1217
KIAA1217
chr5_-_16989371 1.351 NM_012334
MYO10
myosin X
chr5_-_16989290 1.340 MYO10
myosin X
chr10_+_24795465 1.340 KIAA1217
KIAA1217
chr1_+_26376560 1.337 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr9_+_27099138 1.318 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr2_-_151052391 1.313 NM_005168
RND3
Rho family GTPase 3
chr12_-_8706533 1.306 MFAP5
microfibrillar associated protein 5
chr3_-_150533948 1.285 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr3_-_150422474 1.283 NM_000096
CP
ceruloplasmin (ferroxidase)
chr14_+_85066207 1.279 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_-_51173238 1.268 NM_005554
KRT6A
keratin 6A
chr7_+_134114957 1.262 CALD1
caldesmon 1
chr1_-_151848039 1.261 S100A16
S100 calcium binding protein A16
chr6_-_11340869 1.249 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr7_+_134114912 1.232 CALD1
caldesmon 1
chr1_-_85703198 1.229 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_95165089 1.224 NM_001839
CNN3
calponin 3, acidic
chr7_+_96473225 1.184 NM_005222
DLX6
distal-less homeobox 6
chr2_+_223244606 1.180 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr6_-_11340886 1.177 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_56266408 1.172 LOC100129434
hypothetical LOC100129434
chr12_-_8706637 1.153 NM_003480
MFAP5
microfibrillar associated protein 5
chr6_-_11340887 1.133 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr12_-_57600564 1.126 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr11_-_128567302 1.109 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr8_+_40130143 1.105 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr3_-_150578023 1.102 TM4SF1
transmembrane 4 L six family member 1
chr10_+_104525877 1.096 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr16_+_67698943 1.093 NM_005329
HAS3
hyaluronan synthase 3
chr10_+_24538094 1.079 KIAA1217
KIAA1217
chr7_-_27206249 1.072 NM_000522
HOXA13
homeobox A13
chr15_-_70277163 1.071 NM_001012642
GRAMD2
GRAM domain containing 2
chr12_-_87498225 1.069 NM_000899
NM_003994
KITLG

KIT ligand

chr14_+_23008723 1.068 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr4_+_74491272 1.063 ALB
albumin
chr10_+_24537725 1.041 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr3_+_195336625 1.039 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr14_+_22375753 1.034 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_-_6468108 1.030 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr16_+_81218142 1.026 CDH13
cadherin 13, H-cadherin (heart)
chr1_-_177378801 1.020 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr13_+_112704077 1.000 MCF2L
MCF.2 cell line derived transforming sequence-like
chr8_-_22044463 0.994 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr6_+_17390273 0.992 NM_001143941
RBM24
RNA binding motif protein 24
chr4_-_186969041 0.974 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr2_+_54536780 0.974 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr10_+_73393998 0.969 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chrX_-_44945025 0.969 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr5_-_134899537 0.952 NM_006161
NEUROG1
neurogenin 1
chr6_+_114285209 0.940 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr20_-_49818306 0.940 NM_006045
ATP9A
ATPase, class II, type 9A
chr1_-_68470585 0.940 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr3_+_113200696 0.939 NM_001008273
TAGLN3
transgelin 3
chr2_-_160765008 0.937 ITGB6
integrin, beta 6
chr18_+_54039779 0.935 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_23008742 0.931 NGDN
neuroguidin, EIF4E binding protein
chr20_-_49818268 0.929 ATP9A
ATPase, class II, type 9A
chr1_+_200449905 0.925 NM_001017404
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr5_+_149960820 0.923 NM_001166208
SYNPO
synaptopodin
chr5_-_92942680 0.917 FLJ42709
hypothetical LOC441094
chr12_+_62524778 0.917 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr3_+_113200275 0.916 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr16_+_81218074 0.908 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr8_+_70541631 0.892 SULF1
sulfatase 1
chr5_+_178919298 0.891 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr1_+_26376611 0.888 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr2_-_238164042 0.888 RAB17
RAB17, member RAS oncogene family
chr18_+_54039818 0.887 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_62740878 0.884 NM_020663
RHOJ
ras homolog gene family, member J
chr1_+_199975674 0.882 NAV1
neuron navigator 1
chr17_-_71017509 0.878 NM_001142643
CASKIN2
CASK interacting protein 2
chr6_-_28663045 0.877 NM_052923
SCAND3
SCAN domain containing 3
chr5_-_125958503 0.874 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr21_+_17807167 0.874 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr18_+_54039730 0.867 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_44643513 0.865 NM_018150
RNF220
ring finger protein 220
chr18_-_24011349 0.853 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr7_+_72883128 0.848 NM_001305
CLDN4
claudin 4
chr5_+_57914658 0.848 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr8_+_55533047 0.847 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr2_+_37425240 0.846 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr14_+_22375747 0.845 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr4_-_159312973 0.844 FAM198B
family with sequence similarity 198, member B
chr2_+_101680594 0.843 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr4_+_95898098 0.840 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_-_6468600 0.838 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_-_63205948 0.836 ZNF606
zinc finger protein 606
chr4_-_186969202 0.830 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr19_-_56582997 0.830 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr2_+_228386800 0.830 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr6_+_43565192 0.828 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chrX_+_15428820 0.825 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr7_-_27186400 0.820 NM_153715
HOXA10
homeobox A10
chr6_+_17390910 0.816 NM_153020
RBM24
RNA binding motif protein 24
chr8_-_70908130 0.813 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr9_-_72673753 0.808 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr16_+_464844 0.804 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr2_-_45090025 0.800 NM_016932
SIX2
SIX homeobox 2
chr12_-_57600336 0.799 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_+_183970093 0.792 NM_031935
HMCN1
hemicentin 1
chr1_-_223907283 0.787 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr14_-_92284626 0.784 NM_001008530
NM_005606
LGMN

legumain

chr6_-_75972286 0.783 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr15_-_63457378 0.781 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr4_+_146623405 0.779 NM_001003688
SMAD1
SMAD family member 1
chr20_+_60918836 0.772 NM_001853
COL9A3
collagen, type IX, alpha 3
chr21_-_31853160 0.771 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr4_+_185064799 0.769 STOX2
storkhead box 2
chr4_-_159313167 0.765 NM_016613
FAM198B
family with sequence similarity 198, member B
chr20_-_3097070 0.747 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr6_-_75972473 0.747 COL12A1
collagen, type XII, alpha 1
chr13_+_97593411 0.747 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr12_-_129212720 0.745 FLJ31485
hypothetical LOC440119
chr8_+_102573837 0.735 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr1_-_16411690 0.732 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr17_+_72795567 0.731 NM_001113492
SEPT9
septin 9
chr15_+_96304942 0.730 ARRDC4
arrestin domain containing 4
chr15_+_37660568 0.722 NM_003246
THBS1
thrombospondin 1
chr13_+_97593469 0.721 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr16_-_78192111 0.713 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr17_+_8154280 0.712 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr4_+_185064876 0.712


chr1_+_42701460 0.706 CCDC30
coiled-coil domain containing 30
chr11_-_116213511 0.703 NM_000039
APOA1
apolipoprotein A-I
chr22_+_31527678 0.696 TIMP3
TIMP metallopeptidase inhibitor 3
chr18_+_7936885 0.694 PTPRM
protein tyrosine phosphatase, receptor type, M
chr8_+_70541412 0.686 NM_001128204
NM_015170
SULF1

sulfatase 1

chr15_+_96304911 0.685 NM_183376
ARRDC4
arrestin domain containing 4
chr20_+_31613800 0.685 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr20_-_17459973 0.683 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr14_-_94306104 0.682 NM_173849
GSC
goosecoid homeobox
chr7_-_107430566 0.678 NM_002291
LAMB1
laminin, beta 1
chr3_-_27739201 0.677 EOMES
eomesodermin
chr1_-_94475840 0.670 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr20_-_38751289 0.665 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr22_+_31527744 0.662 TIMP3
TIMP metallopeptidase inhibitor 3
chr1_+_144439069 0.661 NM_002614
PDZK1
PDZ domain containing 1
chr3_-_121883647 0.660 HGD
homogentisate 1,2-dioxygenase
chr17_-_1359745 0.660 INPP5K
inositol polyphosphate-5-phosphatase K
chr3_+_51397756 0.657 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr7_-_41709191 0.654 NM_002192
INHBA
inhibin, beta A
chr5_-_127901376 0.653 FBN2
fibrillin 2
chr10_-_91451102 0.653 NBAS
neuroblastoma amplified sequence
chr2_-_88208650 0.652 NM_001443
FABP1
fatty acid binding protein 1, liver
chr4_-_110942576 0.648 CFI
complement factor I
chr15_-_53822468 0.648 NM_173814
PRTG
protogenin
chr5_-_146813343 0.648 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr3_+_195336631 0.647 HES1
hairy and enhancer of split 1, (Drosophila)
chrX_+_85290106 0.646 NM_001139514
NM_053281
DACH2

dachshund homolog 2 (Drosophila)

chrX_+_85290117 0.645 DACH2
dachshund homolog 2 (Drosophila)
chr6_-_138862271 0.640 NM_001144060
NHSL1
NHS-like 1
chr3_+_182912405 0.636 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr9_+_22103542 0.635 CDKN2B-AS1
CDKN2B antisense RNA 1 (non-protein coding)
chr14_-_37795290 0.632 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr1_-_108032645 0.628 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr9_+_115303527 0.628 NM_130795
RGS3
regulator of G-protein signaling 3
chr4_-_101658094 0.625 NM_001159694
NM_016242
EMCN

endomucin

chr8_+_95722575 0.623 ESRP1
epithelial splicing regulatory protein 1
chr4_-_159313613 0.623 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr12_+_52665196 0.622 NM_017409
HOXC10
homeobox C10
chr2_-_239987557 0.611 NM_006037
HDAC4
histone deacetylase 4
chr1_+_246178701 0.608 NM_001001963
OR2L8
olfactory receptor, family 2, subfamily L, member 8

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 4.05e-09 GO:0048856 anatomical structure development
1.37 1.51e-08 GO:0007275 multicellular organismal development
1.41 2.00e-08 GO:0048731 system development
1.27 2.04e-08 GO:0032501 multicellular organismal process
1.60 4.84e-08 GO:0007399 nervous system development
1.34 6.60e-08 GO:0032502 developmental process
1.20 1.34e-06 GO:0050794 regulation of cellular process
1.19 2.45e-06 GO:0050789 regulation of biological process
1.18 2.73e-06 GO:0065007 biological regulation
1.42 1.82e-05 GO:0048869 cellular developmental process
1.42 2.24e-05 GO:0030154 cell differentiation
1.49 5.14e-05 GO:0009653 anatomical structure morphogenesis
2.03 6.27e-05 GO:0007264 small GTPase mediated signal transduction
1.65 1.51e-04 GO:0048699 generation of neurons
1.68 2.97e-04 GO:0071844 cellular component assembly at cellular level
1.61 3.59e-04 GO:0022008 neurogenesis
1.54 7.19e-04 GO:0022607 cellular component assembly
1.27 7.88e-04 GO:0016043 cellular component organization
1.88 1.17e-03 GO:0007409 axonogenesis
1.82 1.87e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.65 2.85e-03 GO:0009790 embryo development
2.03 3.36e-03 GO:0030029 actin filament-based process
1.68 3.43e-03 GO:0032989 cellular component morphogenesis
1.57 3.86e-03 GO:0040011 locomotion
1.81 3.92e-03 GO:0048812 neuron projection morphogenesis
1.25 4.10e-03 GO:0071840 cellular component organization or biogenesis
1.82 4.31e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.30 4.63e-03 GO:0071842 cellular component organization at cellular level
1.09 5.36e-03 GO:0009987 cellular process
1.93 5.90e-03 GO:0007411 axon guidance
1.57 5.96e-03 GO:0051128 regulation of cellular component organization
1.75 6.60e-03 GO:0000904 cell morphogenesis involved in differentiation
1.16 6.96e-03 GO:0050896 response to stimulus
2.07 8.66e-03 GO:0030036 actin cytoskeleton organization
1.59 8.74e-03 GO:2000026 regulation of multicellular organismal development
1.52 9.83e-03 GO:0048468 cell development
1.61 1.00e-02 GO:0030182 neuron differentiation
1.65 1.57e-02 GO:0000902 cell morphogenesis
1.84 1.59e-02 GO:0043009 chordate embryonic development
1.51 1.73e-02 GO:0050793 regulation of developmental process
1.71 1.76e-02 GO:0048858 cell projection morphogenesis
1.82 2.29e-02 GO:0009792 embryo development ending in birth or egg hatching
1.69 2.39e-02 GO:0032990 cell part morphogenesis
1.39 2.65e-02 GO:0009966 regulation of signal transduction
1.43 3.07e-02 GO:0044085 cellular component biogenesis
1.71 3.14e-02 GO:0072358 cardiovascular system development
1.71 3.14e-02 GO:0072359 circulatory system development
1.26 3.24e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.80 3.29e-02 GO:0048598 embryonic morphogenesis
1.22 3.84e-02 GO:0023052 signaling
1.70 4.88e-02 GO:0048870 cell motility
1.70 4.88e-02 GO:0051674 localization of cell

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.72 1.30e-04 GO:0030054 cell junction
1.36 3.70e-03 GO:0005856 cytoskeleton
2.20 5.78e-03 GO:0070161 anchoring junction
3.01 1.19e-02 GO:0000786 nucleosome
2.21 1.23e-02 GO:0005912 adherens junction
1.81 2.38e-02 GO:0015629 actin cytoskeleton
1.18 4.08e-02 GO:0005886 plasma membrane
1.17 4.50e-02 GO:0071944 cell periphery
1.87 4.58e-02 GO:0016323 basolateral plasma membrane
1.67 4.84e-02 GO:0031012 extracellular matrix
7.85 4.97e-02 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 2.30e-06 GO:0005515 protein binding
1.09 1.66e-04 GO:0005488 binding
1.68 1.05e-02 GO:0030695 GTPase regulator activity
1.66 1.36e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.85 1.65e-02 GO:0005083 small GTPase regulator activity
3.57 2.32e-02 GO:0003823 antigen binding
1.43 4.18e-02 GO:0030234 enzyme regulator activity